International Projects

Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risk evaluation and model development (REfraME)
Program: H2020-EU.3.1, Ref No.: 643417
Project Coordinator: Giuseppe Legname, SISSA, Trieste, Italy
Duration: Jan 1, 2015 – Dec 31, 2018
Participating investigators:
  • A. Aguzzi (University of Zurich),
  • M. Goedert (MRC Laboratory of Molecular Biology, UK),
  • M. Jucker (DZNE, Germany),
  • G. Di Fede (IRCCS Foundation Carlo Besta Neurological Institute, Italy),
  • J-Y. Li (Lund University, Sweden)
  • M. Novak (NIU, Slovakia)
REfraME countries
SyDAD Synaptic Dysfunction in Alzheimer Disease
Program: H2020-EU.1.3.1., Ref No.: 676144
Project Coordinator: Bengt Winblad, KAROLINSKA INSTITUTET, Sweden
Duration: Nov 1, 2015 – Oct 31, 2019
SyDAD countries
Repetitive Subconcussive Head Impacts -Brain Alterations and Clinical Consequences
Program: ERANET
Project Coordinator: Inga Katharina Koerte, MD PhD, Ludwig-Maximilians-Universität München, Department of Child and Adolescent Psychiatry, Psychosomatics, Germany
Project Co-investigator: Assoc. Prof. Peter Filipcik, RNDr, PhD
Duration: January 1, 2017 – 31 December 2019
ERANET
 

Spinal cord repair: releasing the neuron-intrinsic brake on axon regeneration
AxonRepair – –
Program: ERANET
Project leader: MVDr. Čižková Dáša DrSc.
Duration: 1.1.2017 – 31.12.2019
Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases
JPsustaiND – Coordination Action in support of the sustainability and globalisation of the Joint Programming Initiative on Neurodegenerative Diseases
Program: Horizon 2020
Project leader: prof. MVDr. Novák Michal DrSc., Dr.h.c.
Duration: 1.11.2015 – 1.11.2019
Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risks evaluation and model development
REfrAME – Mechanizmy patologickej transformácie proteínov pri neurodegeneračných ochoreniach: nové prístupy vyhodnotenia rizík a vývoj modelov
Program: Horizon 2020
Project leader: prof. MVDr. Novák Michal DrSc., Dr.h.c.
Duration: 1.5.2016 – 30.4.2019
Non-globular proteins – from sequence to structure, function and application in molecular physiopathology (NGP-NET)
NGP-NET – Ne-globulárne bielkoviny, ich sekvencia, štruktúra, funkcia a zapojenie v molekulárnej normálnej a patologickej fyziológii
Program: COST
Project leader: RNDr. Škrabana Rostislav PhD.
Annotation: Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.
Duration: 31.5.2015 – 25.3.2019