Finished Projects

View projects over the past five years.

International

REfrAME – Mechanizmy patologickej transformácie proteínov pri neurodegeneračných ochoreniach: nové prístupy vyhodnotenia rizík a vývoj modelov
Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risks evaluation and model development
Program: Horizon 2020
Project leader: Dr. h. c. prof. MVDr. Novák Michal DrSc.
Duration: 1.5.2016 – 30.4.2019
NGP-NET – Ne-globulárne bielkoviny, ich sekvencia, štruktúra, funkcia a zapojenie v molekulárnej normálnej a patologickej fyziológii
Non-globular proteins – from sequence to structure, function and application in molecular physiopathology (NGP-NET)
Program: COST
Project leader: RNDr. Škrabana Rostislav PhD.
Annotation: Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.
Duration: 31.5.2015 – 25.3.2019
BIOMARKAPD – Biomarkery pre Alzheimerovu a Parkinsonovu chorobu
Biomarkers for Alzheimer’s disease and Parkinson’s disease
Program: Multilateral – other
Project leader: Doc. MVDr. Žilka Norbert DrSc.
Annotation: Neurodegenerative disorders, represented mostly by Alzheimer’s disease (AD) and Parkinson’sdisease (PD), are characterised by progressive neuronal impairment and death. In spite of the brain’sknown capacity for regeneration, lost neurons generally cannot be replaced. Therefore, drugs aimedat inhibiting neurodegenerative processes are likely to be most effective if the treatment is initiated asearly as possible in the disease process. However, clinical manifestations in early disease stages areoften difficult to diagnose. This is where biomarkers, specifically reflecting the onset of pathology mayhave a profound impact on diagnosis and detection of treatment effects in the near future. A triplet ofcerebrospinal fluid (CSF) biomarkers for AD, total and hyperphosphorylated tau that reflect AD-typeaxonal degeneration, and the 42 amino acid isoform of amyloid beta that reflects senile plaque pathology, has already been established for early detection of AD before the onset of dementia. With regards to PD, the most promising biomarker is CSF alpha-synuclein. However, large variations in all biomarker measurements have been reported between studies, both between and within centres andlaboratories. Such variations may be caused by pre-analytical, analytical, or assay-related factors andseriously jeopardize the introduction of biomarkers in clinical routine and trials around the world.
Duration: 1.6.2012 – 1.6.2015

National

Dokáže aktívna stimulácia mozgu zastaviť šírenie neurofibrilárnej degenerácie?
Is it possible to stop the spreading of neurofibrillary degeneration by active stimulation of the brain?
Program: VEGA
Project leader: Doc. MVDr. Žilka Norbert DrSc.
Duration: 1.1.2016 – 31.12.2018
Inhibícia expresie prirodzene nezvinutých proteínov a jej dôsledky pre progresiu neurodegeneratívnych zmien
Inhibtion of expression of natively unfolded proteins and its consequence for progression of neurodegeneration
Program: VEGA
Project leader: doc. RNDr. Filipčík Peter CSc.
Duration: 1.1.2016 – 31.12.2018
MOLEKULÁRNY PROFIL MIRNA A ZMENY GÉNOVEJ EXPRESIE V MODELI ĽUDSKÝCH TAUOPATIÍ
Molecular profiling of miRNA and gene expression changes in a model of human tauopathy
Program: VEGA
Project leader: RNDr. Čente Martin PhD.
Duration: 1.1.2015 – 31.12.2018
Starnutie imunitného systému a biologické markery imunosenescencie
The aging of the immune system and biomarkers of human immunosenescence
Program: VEGA
Project leader: RNDr. Prčina Michal PhD.
Duration: 1.1.2016 – 31.12.2018
ŠTRUKTÚRA SEKVENČNE HOMOLÓGNYCH EPITOPOV VIACNÁSOBNE PRÍTOMNÝCH NA MOLEKULE PRIRODZENE NEUSPORIADANÉHO PROTEÍNU TAU
Structural study of multiple homologous epitopes present on the molecule of intrinsically disordered protein tau
Program: VEGA
Project leader: Ing. Cehlár Ondrej PhD.
Duration: 1.1.2015 – 31.12.2018
Zmeny funkcie kôrových neurónov pri Alzheimerovej chorobe
Functional impact of Alzheimer\’s disease on cortical neurons
Program: VEGA
Project leader: MUDr., Mgr. Hromádka Tomáš PhD.
Duration: 1.1.2016 – 31.12.2018
MODEL BUNKOVEJ KOMUNIKÁCIE MEDZI NERVOVÝM A IMUNITNÝM SYSTÉMOM V ALZHEIMEROVEJ CHOROBE
The model of the neuroimmune crosstalk in Alzheimer´s disease
Program: SRDA
Project leader: Doc. MVDr. Žilka Norbert DrSc.
Duration: 1.7.2015 – 30.6.2018
VÝVOJ NOVÉHO PEPTIDOVÉHO SYSTÉMU PRE TRANSPORT LIEČIV DO MOZGU
Development of novel peptide based system for delivery of therapeutics into the brain
Program: SRDA
Project leader: PharmDr. Kováč Andrej PhD.
Duration: 1.7.2015 – 30.6.2018
Nová kombinovaná terapia na báze alginátových biomateriálov a trofických faktorov pre obnovu poranenej miechy
A novel combined therapy based on alginate biomaterials and trophic factors for spinal cord injury repair
Program: SRDA
Project leader: doc. MVDr. Čížková Daša DrSc.
Duration: 1.1.2016 – 31.12.2017
POŠKODENIE MOZGOVO-CIEVNEJ BARIÉRY V PROSTREDÍ NEURODEGENERÁCIE U TRANSGÉNNYCH POTKANÍCH MODELOV PRE TAUOPÁTIE
Damage of the blood-brain barrier of transgenic rat models for tauopathies
Program: VEGA
Project leader: PharmDr. Kováč Andrej PhD.
Duration: 1.1.2015 – 31.12.2017
BIOFYZIKÁLNA ANALÝZA N-KONCOVEJ DOMÉNY PROTEÍNU TAU MODEL PRE PRIRODZENE NEUSPORIADANÝ POLYPEPTID: DÔSLEDKY PRE NEURODEGENERAČNÉ TAUOPÁTIE
Biophysics and structure of intrinsically disordered polypeptides studied on the N-terminal tail of tau protein: implications for neurodegenerative tauopathies
Program: VEGA
Project leader: RNDr. Škrabana Rostislav PhD.
Duration: 1.1.2013 – 31.12.2016
KONVERZIA NEURONÁLNÉHO PROTEÍNU TAU NA PATOLOGICKÉ FORMY VO ZVIERACOM MODELI NEUROFIBRILÁRNEJ DEGENERÁCIE
Conversion of the neuronal protein tau into pathological forms in the animal model of neurofibrillary degeneration
Program: VEGA
Project leader: Mgr. Kováčech Branislav PhD.
Duration: 1.1.2013 – 31.12.2016
MOLEKULÁRNE MECHANIZMY DYSREGULÁCIE PROTEOSTÁZY V NEURODEGENERATÍVNYCH PROTEINOPÁTIÁCH
Identification of molecular mechanisms underlying dysregulated proteostasis in neurodegenerative proteinopathy
Program: VEGA
Project leader: RNDr. Žilková Monika PhD.
Duration: 1.1.2014 – 31.12.2016
ETIOPATOGENÉZA NEURODEGENERATÍVNYCH OCHORENÍ: VÝZNAM POSTTRANSKRIPČNEJ ÚPRAVY RNA PRE VZNIK A PROGRESIE SPORADICKÝCH TAUOPÁTIÍ A ALZHEIMEROVEJ CHOROBY
Etiopathogenesis of neurodegenerative diseases: focus on RNA processing regulation in development and progression of sporadic tauopathies and Alzheimer´s disease
Program: SRDA
Project leader: doc. RNDr. Filipčík Peter CSc.
Duration: 1.10.2013 – 30.9.2016
ŠTÚDIUM FUNKCIE TAU PROTEÍNU V JADRÁCH NEURÓNOV
Studies of tau protein functions in nuclei of neurons
Program: VEGA
Project leader: Mgr. Baráth Peter PhD.
Annotation: Neurofibrillary tangles, one of the hallmarks of Alzheimer\’s disease (AD),are composed of missfolded tau protein that belongs to the family of microtubule-associated proteins. The transition between normal and pathological tau proteins is driven by post-translational modifications and partial proteolytic cleavage. It is generally assumed that the main function of tau involves regulation of the dynamics of neuronal microtubules. Recently, this typical cytosolic protein has been shown to translocate to the nucleus where it might participate in DNA protection upon stress. Within the project, we will study nuclear tau shuttling mechanism using cellular models expressing truncated forms, some of which cause development of AD-like symptoms in transgenic rat. We will also explore the mechanism of DNA protection that includes description of nuclear tau interactome and FISH analysis of chromosomal regions recognized by tau. The study will provide new perspective on physiological and pathological roles of tau protein.
Duration: 1.1.2012 – 31.12.2015
UBIQUITÍN- PROTEAZÓMOVÝ SYSTÉM A JEHO AKTIVITA V BUNKOVOM MODELY NEURODEGRADÁCIE: IMPLIKÁCIE PRE ETIOPATOGENÉZU DEGENERATÍVNYCH OCHORENÍ MOZGU
Ubiquitin proteasomal system and it’s activity in cellular model of neurodegeneration: implications for etiopathogenesis of degenerative diseases of brain
Program: VEGA
Project leader: doc. RNDr. Filipčík Peter CSc.
Duration: 1.1.2013 – 31.12.2015
Brain centrum – CENTRUM EXCELENTNOSTI PRE VÝSKUM MOZGU SAV
Program: Centrá excelentnosti SAV
Project leader: Doc. MVDr. Žilka Norbert DrSc.
Duration: 4.8.2011 – 3.8.2015
MECHANIZMUS INTERAKCIE IMUNITNÉHO A NERVOVÉHO SYSTÉMU V PROCESE NEURODEGENERÁCIE MOZGU
Mechnism of immune and neuronal system interaction in the brain during neurodegeneration
Program: SRDA
Project leader: RNDr. Žilková Monika PhD.
Duration: 1.7.2012 – 30.6.2015
RIZIKOVÉ FAKTORY A PROTEOMICKÝ RUKOPIS KOGNITÍVNYCH DYSFUNKCIÍ ANIMÁLNYCH MODELOV PRE ĽUDSKÉ DEMENCIE
Risk factors and proteomic signature of cognitive dysfunctions in animal models for human dementias
Program: SRDA
Project leader: Doc. MVDr. Žilka Norbert DrSc.
Duration: 1.7.2012 – 30.6.2015
ANALÝZY INERAKČNÝCH PARTNEROV PRIÓNOVÉHO PROTEÍNU A ICH FUNKČNÝ VÝZNAM
Analysis of prion protein interaction partners and their functional significance
Program: VEGA
Project leader: prof. RNDr. Kontseková Eva DrSc.
Duration: 1.1.2012 – 31.12.2014
VPLYV RNA SEKUNDÁRNEJ ŠTRUKTÚRY NA EFEKTIVITU ZOSTRIHU PREKURZOROVEJ MRNA. IMPLIKÁCIA PRE REGULÁCIU SYNTÉZY TAU EXÓN 10 +/- IZOFORIEM
Effect RNA secondary structure on RNA splicing effciency. Implication for regulation sythesis of tau exon10 +/-
Program: VEGA
Project leader: Mgr. Královičová Jana PhD
Duration: 1.1.2012 – 31.12.2014
JE STRES JEDNÝM Z PODSTATNÝCH FAKTOROV NEURODEGENERAČNÉHO PROCESU PRI ALZHEIMEROVEJ CHOROBE?
Is stress a crucial factor in the process of neurodegeneration accompanying Alzheimer´s disease?
Program: SRDA
Project leader: doc. RNDr. Filipčík Peter CSc.
Duration: 1.5.2011 – 31.10.2014